abstract：:The morphology of the toe epithelium of the rock frog, Staurois parvus (Family Ranidae), was investigated using a variety of microscopical techniques. The toe pad epithelium is stratified (four to five cell layers), the apical parts of the cells of the outermost layer being separated by fluid-filled channels. The surf...

journal_title：Interface focus

authors： Drotlef DM,Appel E,Peisker H,Dening K,Del Campo A,Gorb SN,Barnes WJ

更新日期：2015-02-06 00:00:00

abstract：:The development of bioadhesives inspired from marine animals is a promising approach to generate new tissue-compatible medical components. A number of marine species, through their adhesive properties, also represent significant foulers that become increasingly problematic to aquaculture, shipping or local biodiversit...

journal_title：Interface focus

authors： Pennati R,Rothbächer U

更新日期：2015-02-06 00:00:00

abstract：:A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membra...

journal_title：Interface focus

authors： West T,Ashmore J

更新日期：2014-12-06 00:00:00

abstract：:Blood glucose levels are controlled by well-known physiological feedback loops: high glucose levels promote insulin release from the pancreas, which in turn stimulates cellular glucose uptake. Low blood glucose levels promote pancreatic glucagon release, stimulating glycogen breakdown to glucose in the liver. In healt...

journal_title：Interface focus

authors： Csete M,Doyle J

更新日期：2014-10-06 00:00:00

abstract：:One of the predictions of game theory is that cooperative behaviours are vulnerable to exploitation by selfish individuals, but this result seemingly contradicts the survival of cooperation observed in nature. In this review, we will introduce game theoretical concepts that lead to this conclusion and show how the spa...

journal_title：Interface focus

authors： Lambert G,Vyawahare S,Austin RH

更新日期：2014-08-06 00:00:00

abstract：:Multi-site enzymes, defined as where multiple substrate molecules can bind simultaneously to the same enzyme molecule, play a key role in a number of biological networks, with the Escherichia coli protease ClpXP a well-studied example. These enzymes can form a low latency 'waiting line' of substrate to the enzyme's ca...

journal_title：Interface focus

authors： Hochendoner P,Ogle C,Mather WH

更新日期：2014-06-06 00:00:00

abstract：:Apart from interacting, prey and predators may also avoid each other by moving into refuges where they lack food, yet survive by switching to an energy-saving physiological state. Lotka-Volterra models of predator-prey interactions ignore this option. Therefore, we have modelled this game of 'joining versus opting out...

journal_title：Interface focus

authors： Staňková K,Abate A,Sabelis MW,Buša J,You L

更新日期：2013-12-06 00:00:00

abstract：:A tumour is a heterogeneous population of cells that competes for limited resources. In the clinic, we typically probe the tumour by biopsy, and then characterize it by the dominant genetic clone. But genotypes are only the first link in the chain of hierarchical events that leads to a specific cell phenotype. The rel...

journal_title：Interface focus

authors： Gallaher J,Anderson AR

更新日期：2013-08-06 00:00:00

abstract：:Noble metal nanoparticles (NPs) show distinctive plasmonic optical properties and superior photostability, enabling them to serve as photostable multi-coloured optical molecular probes and sensors for real-time in vivo imaging. To effectively study biological functions in vivo, it is essential that the NP probes are b...

journal_title：Interface focus

authors： Browning LM,Huang T,Xu XH

更新日期：2013-06-06 00:00:00

abstract：:We construct the components for a family of computational models of the electrophysiology of the human foetal heart from 60 days gestational age (DGA) to full term. This requires both cell excitation models that reconstruct the myocyte action potentials, and datasets of cardiac geometry and architecture. Fast low-angl...

journal_title：Interface focus

authors： Pervolaraki E,Anderson RA,Benson AP,Hayes-Gill B,Holden AV,Moore BJ,Paley MN,Zhang H

更新日期：2013-04-06 00:00:00

abstract：:Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features t...

journal_title：Interface focus

authors： Groen D,Borgdorff J,Bona-Casas C,Hetherington J,Nash RW,Zasada SJ,Saverchenko I,Mamonski M,Kurowski K,Bernabeu MO,Hoekstra AG,Coveney PV

更新日期：2013-04-06 00:00:00

abstract：:Biofuels production from microalgae attracts much attention but remains an unproven technology. We explore routes to enhance production through modifications to a range of generic microalgal physiological characteristics. Our analysis shows that biofuels production may be enhanced ca fivefold through genetic modificat...

journal_title：Interface focus

authors： Flynn KJ,Mitra A,Greenwell HC,Sui J

更新日期：2013-02-06 00:00:00

abstract：:Formation of spatial patterns of cells is a recurring theme in biology and often depends on regulated cell motility. Motility of the rod-shaped cells of the bacterium Myxococcus xanthus depends on two motility machineries, type IV pili (giving rise to S-motility) and the gliding motility apparatus (giving rise to A-mo...

journal_title：Interface focus

authors： Starruß J,Peruani F,Jakovljevic V,Søgaard-Andersen L,Deutsch A,Bär M

更新日期：2012-12-06 00:00:00

abstract：:Yves Bouligand's analysis of the organizations of biological materials in relation to those of liquid crystals enabled the development of the idea that physical forces exerting their actions under strong spatial constraints determine the structures and morphologies of these materials. The different levels of organizat...

journal_title：Interface focus

authors： Charvolin J,Sadoc JF

更新日期：2012-10-06 00:00:00

abstract：:We investigate, by molecular dynamics simulation, the behaviour of discotic particles in a solvent of Lennard-Jones spheres. When chromonic disc-sphere interactions are imposed on these systems, three regimes of self-assembly are observed. At moderate temperatures, numerous short threads of discs develop, but these th...

journal_title：Interface focus

authors： Prybytak P,Frith WJ,Cleaver DJ

更新日期：2012-10-06 00:00:00

abstract：:The paper reviews two computing models by DNA self-assembly whose proof of principal have recently been experimentally confirmed. The first model incorporates DNA nano-devices and triple crossover DNA molecules to algorithmically arrange non-DNA species. This is achieved by simulating a finite-state automaton with out...

journal_title：Interface focus

authors： Jonoska N,Seeman NC

更新日期：2012-08-06 00:00:00

abstract：:Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The cells specifically migrate to destiny sites induced by the gradually varying conce...

journal_title：Interface focus

authors： Wu J,Mao Z,Tan H,Han L,Ren T,Gao C

更新日期：2012-06-06 00:00:00

abstract：:Most ecological interactions occur in environments that are spatially and temporally heterogeneous-'patchy'-across a wide range of scales. In contrast, most theoretical models of ecological interactions, especially large-scale models applied to societal issues such as climate change, resource management and human heal...

journal_title：Interface focus

authors： Grünbaum D

更新日期：2012-04-06 00:00:00

abstract：:In areas of oil and gas exploration, seismic lines have been reported to alter the movement patterns of wolves (Canis lupus). We developed a mechanistic first passage time model, based on an anisotropic elliptic partial differential equation, and used this to explore how wolf movement responses to seismic lines influe...

journal_title：Interface focus

authors： McKenzie HW,Merrill EH,Spiteri RJ,Lewis MA

更新日期：2012-04-06 00:00:00

abstract：:Must higher level biological processes always be derivable from lower level data and mechanisms, as assumed by the idea that an organism is completely defined by its genome? Or are higher level properties necessarily also causes of lower level behaviour, involving actions and interactions both ways? This article uses ...

journal_title：Interface focus

authors： Noble D

更新日期：2012-02-06 00:00:00

abstract：:Dynamic remodelling of actin stress fibres (SFs) allows non-muscle cells to adapt to applied forces such as uniaxial cell shortening. However, the mechanism underlying rapid and selective disassembly of SFs oriented in the direction of shortening remains to be elucidated. Here, we investigated how myosin crossbridge c...

journal_title：Interface focus

authors： Matsui TS,Kaunas R,Kanzaki M,Sato M,Deguchi S

更新日期：2011-10-06 00:00:00

abstract：:Ultrasound elastography is a technique used for clinical imaging of tissue stiffness with a conventional ultrasound machine. It was first proposed two decades ago, but active research continues in this area to the present day. Numerous clinical applications have been investigated, mostly related to cancer imaging, and...

journal_title：Interface focus

authors： Treece G,Lindop J,Chen L,Housden J,Prager R,Gee A

更新日期：2011-08-06 00:00:00

abstract：:There is a growing need for patient-specific and holistic modelling of the heart to support comprehensive disease assessment and intervention planning as well as prediction of therapeutic outcomes. We propose a patient-specific model of the whole human heart, which integrates morphology, dynamics and haemodynamic para...

journal_title：Interface focus

authors： Mihalef V,Ionasec RI,Sharma P,Georgescu B,Voigt I,Suehling M,Comaniciu D

更新日期：2011-06-06 00:00:00

abstract：:We present the development of a tool, which provides users with the ability to visualize and interact with a comprehensive description of a multi-scale model of the renal nephron. A one-dimensional anatomical model of the nephron has been created and is used for visualization and modelling of tubule transport in vario...

journal_title：Interface focus

authors： Nickerson DP,Terkildsen JR,Hamilton KL,Hunter PJ

更新日期：2011-06-06 00:00:00

abstract：:Biofuels have gained increasing attention as an alternative to fossil fuels for several reasons, one of which is their potential to reduce the greenhouse gas (GHG) emissions from the transportation sector. Recent studies have questioned the validity of claims about the potential of biofuels to reduce GHG emissions rel...

journal_title：Interface focus

authors： Khanna M,Crago CL,Black M

更新日期：2011-04-06 00:00:00

abstract：:This article uses an integrative systems biological view of the relationship between genotypes and phenotypes to clarify some conceptual problems in biological debates about causality. The differential (gene-centric) view is incomplete in a sense analogous to using differentiation without integration in mathematics. D...

journal_title：Interface focus

authors： Noble D

更新日期：2011-02-06 00:00:00

abstract：:Pancreatic β-cells use Ca(2+)-dependent exocytosis of large dense core vesicles to release insulin. Exocytosis in β-cells has been studied biochemically, biophysically and optically. We have previously developed a biophysical method to monitor release of endogenous intragranular constituents that are co-released with ...

journal_title：Interface focus

authors： Galvanovskis J,Braun M,Rorsman P

更新日期：2011-02-06 00:00:00